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        Dr. Joe Li received his PhD in Biophysics from Brandeis University, and his postdoctoral training at Boston Biomedical Research Institute.  He went on to found Li International (2007), a consulting firm serving the biotech and chemical industries.  In recent years, the company has placed most of its effort on the development of biological reagents, especially antibodies.

        Joe has published several important papers on protein structures and muscle regulation.  He was the developer of the AccuTope prediction algorithm, which chooses antigen fragments from proteins using both sequence and structural data.  Currently, he serves as the CEO of our company, and oversees our custom antibody program in his capacity as Senior Scientist.

List of Publications

Research Articles

1. Borrego-Diaz, E., Kerff, F., Lee, S. H., Ferron, F., Li, Y. & Dominguez, R. (2006)  Crystal structure of the actin-binding domain of alpha-actinin 1: Evaluating two competing actin-binding models.  J. Structural Biology 155:230-238.

2. LI, Y., Brown, J. H., Reshetnikova, L., Blazsek, A., Farkas, L., Nyitray, L. & Cohen, C. (2003). Visualization of an Unstable Coiled Coil from the Scallop Myosin Rod.Nature 424: 341-345.

3. LI, Y., Mui, S., Brown, J. H., Strand, J., Reshetnikova, L., Tobacman, L. S. & Cohen, C. (2002). The Crystal Structure of the C-terminal Fragment of Striated-Muscle α-TropomyosinReveals a Key Troponin T Recognition Site. Proc. Natl. Aca. Sci. USA. 99: 7378-7383.

4. LI, Y., Love, M. L., Putkey, J. A. & Cohen, C. (2000). Bepridil Opens the Regulatory N-terminal Lobe of Cardiac Troponin C. Proc. Natl. Aca. Sci. USA 97: 5140-5145.

5. Jasinski, J. P., Jasinski, J. M., LI, Y. & Crosby, D. J. (2003). 7-Ethylamino-4-(Trifluoromethyl)Coumarin. ActaCryst. E59: o153-o154.

6. Jasinski, J. P. &LI, Y. (2002). 10-(1,3-Benzothiazol-2-yl)-2,3,6,7-Tetrahydro-1H,5H-11H-[1]Benzopyrano[6,7,8-ij]-Quinoliz-11-one. ActaCryst. E58: o1312-o1314.

7. West, D. X., Swearingen, J. K., Romack, T. J., Billeh, I. S., Jasinksi, J. P., LI, Y. & Staples, R. J. (2001). Crystal Structures of Copper (II) Complexes of 2-Formylpyridine Substituted Thiosemicarbazones; the First Example of a Coordinated Thiosemicarbazone with a Thiol Function.J. Mol. Struct. 570: 129-136.

8. Jasinski, J. P., Jasinski, J. M. &LI, Y. (1998). 6,7,8,9-Tetrahydro-4-Trifluoromethyl-2H-Pyrano-[3,2-g]Quinolin-2-One (I) and 6,7,8,9-Tetrahydro-9-Ethyl-4-Trifluoromethyl-2H-Pyrano-[3,2-g]Quinolin-2-One (II). ActaCryst. C54: 410-412.

9. Blackwell, B., Ngola, S. M., Peterson, H., Rosenfeld, S., Tingle, C. W., Jasinski, J. P., LI, Y. &Whittum, J. E. (1998). Two TautomericTrihetero [9] (9,10) Anthracenophanes.J. Org. Chem. 63: 181-184.

10. Muller, C. L., Bever, J. R., Dordel, M. S., Kitabwalla, M. M., Sausker, J. B., Seehafer, T. R., Reineke, T. M., LI, Y. &Jasinski, J. P. (1997). Regiochemistry of IntramolecularPhotocycloaddition of 1,3-Dioxin-4-Ones Tethered through the Ketal Carbon. Tetrahedron Lett. 38: 8663-8666.

11. Ali, M. A., Guan, T. S., Bhattacharjee, P., Butcher, R. J., Jasinski, J. P. &LI, Y. (1996). Nickel(II) and Copper(II) Complexes of ONS Ligands Formed From 2-Hydroxyacetophenone and S-Akyldithiocarbazates and the X-ray Crystal Structure of the (Ni(Ap-SMe)py) Complex (Ap-SMe = Anion of the 2-Hydroxyacetophenone Schiff Base of S-Methyldithiocarbazate). Transition. Met. Chem. 21: 351-357.

12. West, D. X., Bain, G. A., Butcher, R. J., Jasinski, J. P., LI, Y., Pozdniakov, R. Y., Valdez-Martinez, J., Toscano, R. A. & Hernandez-Ortega, S. (1996). Structural Studies of Three Isomeric Forms of Heterocyclic 4N-Substituted Thiosemicarbazones and Two Nickel (II) Complexes. Polyhedron 15: 665-674.

Conference Abstracts

13. Structural Basis of the Actin-Calponin Homology Domain Interaction. Borrego-Diaz, E., Kerff, F., Li, Y. & Dominguez, R. Presentation at the 49th Biophysical Society Meeting, Long Beach, CA, February 17, 2005.

14. Turowski, P. N., Githiora, L. S. W., Andersson, E. J., Jasinski, J. P. &LI, Y. (1997). Structure and Biological Significance of the First Well-Characterized Vanadium(V) Bromo-Coordination Complex. Abstracts of Papers of the American Chemical Society.213: 381-INOR.

15. Ngola, S., Peterson, H., Rosenfeld, S., Tingle, C., Jasinski, J. P., LI, Y. &Whittum, J. E. (1997). Two New Polyhetero[9](9,10)Anthracenophanes. Abstracts of Papers of the American Chemical Society.213: 16-ORGN.


16. Li, Y. Crystallographic Studies of two Regulatory Muscle Proteins: Structures of Cardiac Troponin C and the C-Terminal Region of Striated Muscle Tropomyosin. (UMI and ProQuest, Ann Arbor, MI, 2003).